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ea0032p625 | Growth hormome IGF axis – basic | ECE2013

SNPs within the GH signaling pathway are associated with the fast, but not the long term, IGF1 response to GH replacement therapy in GH deficient adults

Glad Camilla , de Jesus Litenski Barbosa Edna , Filipsson Nystrom Helena , Carlsson Ekander Lena , Nilsson Staffan , Nilsson Anna , Svensson Per-Arne , Johannsson Gudmundur

Introduction: GH deficiency (GHD) in adults is associated with low serum levels of insulin-like growth factor 1 (IGF1) and a deteriorated cardio-metabolic profile. GH replacement therapy (GHRT) increases serum IGF1, an important mediator of the treatment response and safety marker of dose titration. The interindividual variation in treatment response is large and most likely influenced by genetic factors.Aim: The aim of this study was to test the hypothe...

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SNPs within the GH signaling pathway are associated with the fast, but not the long term, IGF1 response to GH replacement therapy in GH deficient adults

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